San Francisco 49ers @ Arizona Cardinals: Nov 16, 2025
49ers vs Cardinals final: the San Francisco 49ers beat the Arizona Cardinals 41-22 on November 16, 2025 at State Farm Stadium, Glendale.
Score by Quarter
| Team | Q1 | Q2 | Q3 | Q4 | T |
|---|---|---|---|---|---|
| 49ers | 13 | 12 | 10 | 6 | 41 |
| Cardinals | 7 | 3 | 0 | 12 | 22 |
49ers vs Cardinals Recap
The 49ers did the damage in the 3rd quarter, winning that period by 10.
After the game, the 49ers are 7-4 and the Cardinals are 3-7.
49ers vs Cardinals Game Info
- Date & time
- Sunday, November 16, 20254:05 PM ET / 1:05 PM PT
- Stadium
- State Farm StadiumGlendale
- Season
- 2025 NFL SeasonRegular season
49ers vs Cardinals: Tale of the Tape
- 6-4
- Record
- 3-6
- NFC #8
- Playoff seed
- NFC #12
- 22.0
- Points per game
- 22.4
- 23.0
- Points allowed
- 23.9
- -1.0
- Point differential
- -1.4
- 4-2
- Road / home record
- 1-3
- 3-1
- Division record
- 0-3
- L1
- Streak
- L1
- 7 days
- Rest
- 7 days
Before this game, from every 2025 regular-season final. Seeds follow the NFL format (division leaders 1-4, Wild Cards 5-7); equal records are split with the NFL tiebreakers.
Recent Form & Head-to-Head
49ers last 5
- L vs Rams 26-42 Nov 9, 2025
- W @ Giants 34-24 Nov 2, 2025
- L @ Texans 15-26 Oct 26, 2025
- W vs Falcons 20-10 Oct 19, 2025
- L @ Buccaneers 19-30 Oct 12, 2025
Cardinals last 5
- L @ Seahawks 22-44 Nov 9, 2025
- W @ Cowboys 27-17 Nov 3, 2025
- L vs Packers 23-27 Oct 19, 2025
- L @ Colts 27-31 Oct 12, 2025
- L vs Titans 21-22 Oct 5, 2025
Previous meetings
- Sep 27, 2026 Cardinals @ 49ers 30-36
- Sep 21, 2025 Cardinals @ 49ers 15-16
More NFL Games on Nov 16, 2025
- Final
Miami Dolphins1-516 - Final
Carolina Panthers3-330
Atlanta Falcons3-427 - Final
- Final
Green Bay Packers4-327
New York Giants4-220 - Final
Houston Texans2-516
Tennessee Titans1-613 - Final
Cincinnati Bengals4-212
Pittsburgh Steelers5-234 - Final
Tampa Bay Buccaneers2-532
Buffalo Bills5-144 - Final
Chicago Bears5-219
Minnesota Vikings6-017 - Final
Seattle Seahawks4-319
Los Angeles Rams3-421 - Final
Kansas City Chiefs5-119
Denver Broncos5-222 - Final
Baltimore Ravens4-323
Cleveland Browns5-216 - Final
Detroit Lions4-29
Philadelphia Eagles2-516
That covers 49ers vs Cardinals: score, leaders and box score above. Next: 49ers host the Raiders Nov 8; Cardinals visit the Cowboys Nov 1.
49ers vs Cardinals FAQs
Who won 49ers vs Cardinals on Nov 16, 2025?
The San Francisco 49ers beat the Arizona Cardinals 41-22 on Sunday, November 16, 2025 at State Farm Stadium in Glendale.
What are the 49ers and Cardinals records?
After this game the 49ers were 7-4 and the Cardinals were 3-7 this season.
Who leads the 49ers vs Cardinals season series?
The 49ers lead the regular-season series 1-0 this season.
Who won the last 49ers vs Cardinals game?
The 49ers beat the Cardinals 36-30 on Sep 27, 2026 at home.
Where was 49ers vs Cardinals played?
At State Farm Stadium in Glendale, the home stadium of the Arizona Cardinals.
What was the score by quarter in 49ers vs Cardinals?
49ers-Cardinals: Q1 13-7, Q2 12-3, Q3 10-0, Q4 6-12.
What is next for the 49ers and Cardinals?
49ers host the Raiders on Sunday, November 8 at 4:25 PM ET; Cardinals visit the Cowboys on Sunday, November 1 at 1:00 PM ET.