Arizona Cardinals @ San Francisco 49ers: Sep 21, 2025
Cardinals vs 49ers final: the San Francisco 49ers beat the Arizona Cardinals 16-15 on September 21, 2025 at Levi's Stadium, Santa Clara.
Score by Quarter
| Team | Q1 | Q2 | Q3 | Q4 | T |
|---|---|---|---|---|---|
| Cardinals | 0 | 3 | 3 | 9 | 15 |
| 49ers | 0 | 6 | 0 | 10 | 16 |
Cardinals vs 49ers Recap
After the game, the Cardinals are 2-1 and the 49ers are 3-0.
Cardinals vs 49ers Game Info
- Date & time
- Sunday, September 21, 20254:25 PM ET / 1:25 PM PT
- Stadium
- Levi's StadiumSanta Clara
- Season
- 2025 NFL SeasonRegular season
Cardinals vs 49ers: Tale of the Tape
- 2-0
- Record
- 2-0
- NFC #5
- Playoff seed
- NFC #2
- 23.5
- Points per game
- 21.5
- 17.5
- Points allowed
- 17.0
- +6.0
- Point differential
- +4.5
- 1-0
- Road / home record
- 0-0
- 0-0
- Division record
- 1-0
- W2
- Streak
- W2
- 7 days
- Rest
- 7 days
Before this game, from every 2025 regular-season final. Seeds follow the NFL format (division leaders 1-4, Wild Cards 5-7); equal records are split with the NFL tiebreakers.
Recent Form & Head-to-Head
Cardinals last 5
- W vs Panthers 27-22 Sep 14, 2025
- W @ Saints 20-13 Sep 7, 2025
49ers last 5
- W @ Saints 26-21 Sep 14, 2025
- W @ Seahawks 17-13 Sep 7, 2025
Previous meetings
- Sep 27, 2026 Cardinals @ 49ers 30-36
- Nov 16, 2025 49ers @ Cardinals 41-22
More NFL Games on Sep 21, 2025
- Final
Houston Texans2-510
Jacksonville Jaguars4-217 - Final
Green Bay Packers4-310
Cleveland Browns5-213 - Final
Cincinnati Bengals4-210
Minnesota Vikings6-048 - Final
Los Angeles Rams3-426
Philadelphia Eagles2-533 - Final
Las Vegas Raiders3-424 - Final
Indianapolis Colts2-541
Tennessee Titans1-620 - Final
Atlanta Falcons3-40
Carolina Panthers3-330 - Final
Pittsburgh Steelers5-221
New England Patriots4-314 - Final
New York Jets2-527
Tampa Bay Buccaneers2-529 - Final
Denver Broncos5-220
Los Angeles Chargers0-623 - Final
New Orleans Saints2-513
Seattle Seahawks4-344 - Final
Dallas Cowboys3-414
Chicago Bears5-231 - Final
Kansas City Chiefs5-122
New York Giants4-29
That covers Cardinals vs 49ers: score, leaders and box score above. Next: Cardinals visit the Cowboys Nov 1; 49ers host the Raiders Nov 8.
Cardinals vs 49ers FAQs
Who won Cardinals vs 49ers on Sep 21, 2025?
The San Francisco 49ers beat the Arizona Cardinals 16-15 on Sunday, September 21, 2025 at Levi's Stadium in Santa Clara.
What are the Cardinals and 49ers records?
After this game the Cardinals were 2-1 and the 49ers were 3-0 this season.
Who leads the Cardinals vs 49ers season series?
The 49ers lead the regular-season series 1-0 this season.
Who won the last Cardinals vs 49ers game?
The 49ers beat the Cardinals 36-30 on Sep 27, 2026 at home.
Where was Cardinals vs 49ers played?
At Levi's Stadium in Santa Clara, the home stadium of the San Francisco 49ers.
What was the score by quarter in Cardinals vs 49ers?
Cardinals-49ers: Q1 0-0, Q2 3-6, Q3 3-0, Q4 9-10.
What is next for the Cardinals and 49ers?
Cardinals visit the Cowboys on Sunday, November 1 at 1:00 PM ET; 49ers host the Raiders on Sunday, November 8 at 4:25 PM ET.