Panthers
PackersSan Francisco 49ers @ Indianapolis Colts: Dec 22, 2025
49ers vs Colts final: the San Francisco 49ers beat the Indianapolis Colts 48-27 on December 22, 2025 at Lucas Oil Stadium, Indianapolis.
Score by Quarter
| Team | Q1 | Q2 | Q3 | Q4 | T |
|---|---|---|---|---|---|
| 49ers | 14 | 10 | 10 | 14 | 48 |
| Colts | 7 | 10 | 3 | 7 | 27 |
49ers vs Colts Recap
The 49ers did the damage in the 1st quarter, winning that period by 7.
After the game, the 49ers are 11-4 and the Colts are 8-7.
49ers vs Colts Game Info
- Date & time
- Monday, December 22, 20258:15 PM ET / 5:15 PM PT
- Stadium
- Lucas Oil StadiumIndianapolis
- Season
- 2025 NFL SeasonRegular season
49ers vs Colts: Tale of the Tape
- 10-4
- Record
- 8-6
- NFC #6
- Playoff seed
- AFC #8
- 24.6
- Points per game
- 28.0
- 20.9
- Points allowed
- 21.6
- +3.6
- Point differential
- +6.4
- 6-2
- Road / home record
- 6-1
- 4-1
- Division record
- 2-2
- W4
- Streak
- L4
- 8 days
- Rest
- 8 days
Before this game, from every 2025 regular-season final. Seeds follow the NFL format (division leaders 1-4, Wild Cards 5-7); equal records are split with the NFL tiebreakers.
Recent Form & Head-to-Head
49ers last 5
- W vs Titans 37-24 Dec 14, 2025
- W @ Browns 26-8 Nov 30, 2025
- W vs Panthers 20-9 Nov 24, 2025
- W @ Cardinals 41-22 Nov 16, 2025
- L vs Rams 26-42 Nov 9, 2025
Colts last 5
- L @ Seahawks 16-18 Dec 14, 2025
- L @ Jaguars 19-36 Dec 7, 2025
- L vs Texans 16-20 Nov 30, 2025
- L @ Chiefs 20-23 Nov 23, 2025
- W vs Falcons 31-25 Nov 9, 2025
That covers 49ers vs Colts: score, leaders and box score above. Next: 49ers host the Raiders Nov 8; Colts visit the Jaguars Nov 1.
49ers vs Colts FAQs
Who won 49ers vs Colts on Dec 22, 2025?
The San Francisco 49ers beat the Indianapolis Colts 48-27 on Monday, December 22, 2025 at Lucas Oil Stadium in Indianapolis.
What are the 49ers and Colts records?
After this game the 49ers were 11-4 and the Colts were 8-7 this season.
Where was 49ers vs Colts played?
At Lucas Oil Stadium in Indianapolis, the home stadium of the Indianapolis Colts.
What was the score by quarter in 49ers vs Colts?
49ers-Colts: Q1 14-7, Q2 10-10, Q3 10-3, Q4 14-7.
What is next for the 49ers and Colts?
49ers host the Raiders on Sunday, November 8 at 4:25 PM ET; Colts visit the Jaguars on Sunday, November 1 at 1:00 PM ET.